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Kunio Matsumoto Selected Research

Hepatocyte Growth Factor (Growth Factor, Hepatocyte)

4/2022N-glycosylation regulates MET processing and signaling.
1/2022SRC kinase activator CDCP1 promotes hepatocyte growth factor-induced cell migration/invasion of a subset of breast cancer cells.
1/2022Dual blockade of MET and VEGFR2 signaling pathways as a potential therapeutic maneuver for peritoneal carcinomatosis in scirrhous gastric cancer.
10/2019Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer.
1/2019Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.
10/2017Hepatocyte growth factor in physiology and infectious diseases.
3/2017Hepatocyte growth factor/MET in cancer progression and biomarker discovery.
1/2017Targeting the hepatocyte growth factor/Met pathway in cancer.
1/2015A clinical protocol to inhibit the HGF/c-Met pathway for malignant mesothelioma with an intrapleural injection of adenoviruses expressing the NK4 gene.
8/2014Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor.
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Kunio Matsumoto Research Topics

Disease

74Neoplasms (Cancer)
01/2022 - 02/2002
24Lung Neoplasms (Lung Cancer)
01/2020 - 02/2002
22Neoplasm Metastasis (Metastasis)
01/2022 - 02/2002
14Fibrosis (Cirrhosis)
01/2013 - 01/2002
12Pancreatic Neoplasms (Pancreatic Cancer)
04/2011 - 01/2002
9Wounds and Injuries (Trauma)
05/2015 - 11/2002
9Ischemia
01/2014 - 06/2001
5Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
04/2022 - 07/2004
4Stomach Neoplasms (Stomach Cancer)
01/2022 - 09/2004
4Mesothelioma
10/2020 - 10/2010
4Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
01/2013 - 07/2002
4Brain Ischemia (Cerebral Ischemia)
10/2006 - 07/2004
3Breast Neoplasms (Breast Cancer)
01/2022 - 07/2006
3Ascites
01/2022 - 09/2004
3Malignant Mesothelioma
10/2020 - 10/2010
3Adenocarcinoma of Lung
06/2017 - 08/2002
3Acute Kidney Injury (Acute Renal Failure)
01/2014 - 03/2009
3Liver Cirrhosis (Hepatic Cirrhosis)
01/2013 - 04/2005
3Respiratory Hypersensitivity
08/2012 - 04/2005
3Reperfusion Injury
01/2012 - 02/2002
3Embolism (Embolus)
10/2006 - 07/2004
3Peripheral Arterial Disease
02/2004 - 09/2002
2Peritoneal Neoplasms
01/2022 - 12/2013
2Hypoxia (Hypoxemia)
10/2017 - 02/2013
2Disease Progression
03/2017 - 03/2006
2Colonic Neoplasms (Colon Cancer)
03/2017 - 06/2004
2Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
05/2015 - 10/2014
2Spinal Cord Injuries (Spinal Cord Injury)
05/2015 - 10/2014
2Chronic Renal Insufficiency
01/2014 - 03/2011
2Renal Insufficiency (Renal Failure)
01/2013 - 01/2002
2Asthma (Bronchial Asthma)
08/2012 - 01/2008
2Myocardial Ischemia (Ischemic Heart Diseases)
06/2012 - 01/2012
2Cardiomyopathies (Cardiomyopathy)
06/2012 - 07/2002
2Hypertrophy
03/2011 - 05/2005
2Lung Injury
03/2009 - 09/2007
2Alcoholic Fatty Liver
08/2008 - 02/2002
2Chronic Kidney Failure (Chronic Renal Failure)
05/2008 - 01/2002
2Inflammation (Inflammations)
01/2008 - 04/2005
2Neurodegenerative Diseases (Neurodegenerative Disease)
11/2006 - 12/2005
2Pulmonary Fibrosis (Fibrosing Alveolitis)
04/2005 - 07/2004
2Infections
01/2005 - 07/2004

Drug/Important Bio-Agent (IBA)

83Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA
04/2022 - 01/2002
18Tyrosine Kinase InhibitorsIBA
04/2022 - 11/2008
18ErbB Receptors (EGF Receptor)IBA
10/2019 - 11/2008
15Proteins (Proteins, Gene)FDA Link
01/2022 - 02/2002
14Proto-Oncogene Proteins c-metIBA
01/2022 - 08/2002
12Gefitinib (Iressa)FDA Link
11/2013 - 03/2006
10Intercellular Signaling Peptides and Proteins (Growth Factors)IBA
01/2022 - 05/2002
9Biological ProductsIBA
10/2017 - 08/2002
9Erlotinib Hydrochloride (CP 358,774)FDA Link
06/2014 - 11/2008
8Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
01/2022 - 09/2011
8LigandsIBA
10/2019 - 08/2006
8Phosphotransferases (Kinase)IBA
03/2016 - 05/2003
7CollagenIBA
10/2020 - 07/2002
7Epoprostenol (Prostacyclin)FDA LinkGeneric
01/2013 - 04/2003
7Angiogenesis InhibitorsIBA
12/2009 - 02/2002
6DNA (Deoxyribonucleic Acid)IBA
06/2017 - 02/2004
6Pharmaceutical PreparationsIBA
01/2017 - 07/2006
6tyrosine receptor (receptor, tyrosine)IBA
03/2016 - 05/2003
6CytokinesIBA
07/2013 - 08/2002
5CrizotinibIBA
03/2016 - 07/2012
5ONO 1301IBA
01/2013 - 01/2012
5ThromboxanesIBA
01/2013 - 01/2012
5Protein-Tyrosine Kinases (Tyrosine Kinase)IBA
01/2011 - 04/2003
4Biomarkers (Surrogate Marker)IBA
12/2021 - 01/2017
4Neutralizing AntibodiesIBA
10/2017 - 09/2012
4AntibodiesIBA
08/2012 - 01/2005
4Therapeutic UsesIBA
08/2012 - 01/2002
4Matrix Metalloproteinases (MMPs)IBA
08/2011 - 06/2004
4Transforming Growth Factor beta1 (TGF beta 1)IBA
03/2006 - 11/2002
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2022 - 09/2012
3Peptides (Polypeptides)IBA
01/2019 - 02/2002
3WZ4002IBA
01/2013 - 03/2012
3Messenger RNA (mRNA)IBA
01/2013 - 08/2002
3Immunoglobulin G (IgG)IBA
06/2012 - 05/2008
2Bevacizumab (Avastin)FDA Link
10/2017 - 06/2014
2Anaplastic Lymphoma KinaseIBA
03/2017 - 03/2016
2alectinibIBA
03/2016 - 07/2014
2Transforming Growth Factors (Transforming Growth Factor)IBA
08/2014 - 03/2006
24- (2- fluoro- 4- ((((2- phenylacetyl)amino)thioxomethyl)amino)phenoxy)- 7- methoxy- N- methyl- 6- quinolinecarboxamideIBA
06/2014 - 12/2013
2Glycerol (Glycerine)FDA LinkGeneric
01/2014 - 01/2013
2Tyrosine (L-Tyrosine)FDA Link
07/2013 - 10/2010
270-kDa Ribosomal Protein S6 Kinases (Ribosomal Protein S6 Kinases, 70 kDa)IBA
07/2013 - 01/2013
2Phosphatidylinositols (Phosphatidylinositol)IBA
07/2013 - 03/2012
2Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
02/2013 - 11/2008
2Mitogen-Activated Protein KinasesIBA
02/2013 - 05/2004
2AfatinibIBA
01/2013 - 03/2012
2Collagen Type I (Type I Collagen)IBA
01/2013 - 05/2005
2Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
09/2011 - 06/2004
2Culture MediaIBA
04/2009 - 03/2008
2Cisplatin (Platino)FDA LinkGeneric
04/2009 - 09/2004
2Complementary DNA (cDNA)IBA
04/2007 - 10/2002
2Bleomycin (Blenoxane)FDA LinkGeneric
07/2005 - 07/2004
2Transforming Growth Factor beta (TGF-beta)IBA
04/2005 - 01/2002
2Glucose (Dextrose)FDA LinkGeneric
01/2005 - 08/2002

Therapy/Procedure

21Therapeutics
04/2022 - 01/2002
5Intraperitoneal Injections
12/2013 - 02/2002
4Microspheres (Microsphere)
10/2006 - 07/2004
3Aftercare (After-Treatment)
03/2017 - 10/2005
3Radiotherapy
01/2010 - 05/2003